A sniper causes a car accident that nearly kills Stottlemeyer's wife, Karen. Now it's up to Monk to solve the case and keep Stottlemeyer from doing something he might regret.
When Randy's mother marries a guy much younger than her he gets worried. When they go to some kind of couples retreat, he asks Monk and Sharona to go and keep an eye on her. So to go in they pretend to be married.
When an inmate is poisoned to death hours before he's due to be executed, Monk is brought in to solve the case and finds himself as the prison's newest resident.
After Milo tries to steal money from his own company company, his business partner learns of the plan a tries to figure out what to do. Gene turns up dead, and no one ever suspected Milo. Columbo comes to investigate.
An aggressive female pharmaceutical representative stalks the hospital's new chief of staff after a one-night-stand, hoping to break up his marriage and have him all for herself.
Dr. Sloan investigates when an unpopular colleague drops dead while performing an operation. Mark investigates his fellow doctors when tests reveal the deceased was poisoned.
Dr. Sloan and Amanda investigate when the co-pilot of the airplane carrying them to a medical conference is murdered and the remainder of the flight crew are incapacitated with a mysterious illness.
A rare-coin dealer invests his trust in Matlock when he's accused of murdering a thieving employee, while Tyler puts in his two cents when Matlock agrees to let another PI work the case.
Matlock divines the solution to the murder of an amorous model, but forgets it after being hit by a car, and must reconstruct his thoughts from the witness statements.
Fraternal twins Nikki and Nora are forced back into each other's lives when they inherit a detective agency. As they solve a murder, they realize their differences may be their greatest advantage. Stars Hunter King, Rhiannon Fish.
When JAZZ RAMSEY and her crime detection dog ZEUS stumble upon an old crime scene, the K9 trainer, her star pup, and ex-boyfriend and lead detective NICK are thrown into the investigation. Stars Rachel Skarsten, Corey Sevier.